Description
Product Characteristics:
SMC4 is a central component of the condensin complex, which is required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Chromosome associated polypeptide C, hCAP C, XCAP C homolog, CAP C, CAPC, SMC 4, SMC4, SMC4L1, Structural maintenance of chromosomes 4 like 1, SMC4_HUMAN.
Target Information: Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A\, MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]