Description
Product Characteristics:
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].
Subcellular location: Cytoplasm, Nucleus
Synonyms: IKB beta Ser23, IKB beta S23, p-IKB beta Ser23, p-IKB beta S23, NFKBIBSer23, NFKBIBphospho S23, IkB-betaSer22, IkB beta, NF-kappa-B inhibitor beta, IKB beta, NF-kappa-BIB, TRIP-9, I-kappa-B-beta, IkappaBbeta, IkB-beta, IkB-B, Thyroid receptor-interacting protein 9, TR-interacting protein 9, NFKBIB, IKBB.
Target Information: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]