Description
Product Characteristics:
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).
Subcellular location: Cell membrane
Synonyms: DNZ1, DHHC21, DHHC-21, HSPC097, 9130404H11Rik, Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21, ZDHHC21
Target Information: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity)