Description
Product Characteristics:
The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells, its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: ILK-1 phospho S246, ILK-1 phospho Ser246, p-ILK-1 Ser246, 59 kDa serine/threonine protein kinase, 59 kDa serine/threonine-protein kinase, ILK-2, ILK_HUMAN, Integrin linked Kinase, Integrin-linked protein kinase, DKFZp686F1765, EC 2.7.11.1, ILK 1, ILK 2, ILK, ILK1, ILK2, Integrin linked Kinase 2, Integrin linked protein kinase, p59, p59ILK.
Target Information: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]