Description
Product Characteristics:
Dectin 2 is a type II transmembrane protein that is a member of the C type lectin superfamily. In mouse, dectin 2 is predominantly expressed on tissue macrophages and some dendritic cells. Significant expression of Dectin 2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin 2 but transient up regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin 2 has not been fully determined but studies suggest a possible role in immune surveillance.
Subcellular location: Cell membrane
Synonyms: C type lectin domain family 6 member A, C type lectin superfamily member 10, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLC6A_HUMAN, CLEC4N, Clec6a, CLECSF10, DC associated C type lectin 2, DC-associated C-type lectin 2, Dectin-2, Dectin2, Dendritic cell associated lectin 2, Dendritic cell-associated C-type lectin 2.
Target Information: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway