Description
Product Characteristics:
Delta-like 3 (DLL3) is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor and activates Notch signaling.
Synonyms: Delta Drosophila like 3, Delta like 3 Drosophila, Delta like 3 homolog Drosophila, Delta like 3 protein, Delta like protein 3 precursor, Delta3, Drosophila Delta homolog 3, SCDO1, Spondylocostal dysostosis autosomal recessive.DLL3_HUMAN
Target Information: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]