Description
Product Characteristics:
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Subcellular location: Cytoplasm
Synonyms: DOK1 phospho Y398, DOK1 phospho Tyr398, p-DOK1 phospho Y398, docking protein 1 downstream of tyrosine kinase 1, Docking protein 1 p62dok Downstream of tyrosine kinase 1 pp62., docking protein 1 62kD downstream of tyrosine kinase 1, Docking protein 1 62kD, Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK-1, DOK1_HUMAN, Downstream of tyrosine kinase 1, p62dok, P62DOK, pp62, pp62.
Target Information: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]