Description
Product Characteristics:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Subcellular location: Secreted
Synonyms: ACT, AACT, GIG24, GIG25, Alpha-1-antichymotrypsin, Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3
Target Information: The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]