Description
Product Characteristics:
The Annexin family of calcium binding proteins is composed of at least ten mammalian genes. It is characterised by a conserved core domain which binds to phospholipids in a Ca2+ dependent manner and a unique amino terminal region which may confer binding specificity. The Annexin family has been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. When overexpressed in A431 cells, Annexin VI causes a partial reversal of the transformed phenotype.
Subcellular location: Cytoplasm
Synonyms: Annexin VI, 67 kDa calelectrin, Annexin A6, Annexin VI p68, AnnexinA6, AnnexinVI, ANX 6, ANX A6, ANX6, ANXA 6, ANXA6, Calcium binding protein p68, Calelectrin, Calphobindin II, CalphobindinII, CBP 68, CBP68, Chromobindin 20, Chromobindin20, CPB II, CPBII, Lipocortin VI, LipocortinVI, p68, P70, Protein III, ProteinIII.
Target Information: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]