Description
Product Characteristics:
CDKN3 is a second dual specificity phosphatase that interacts with cyclin dependent kinases.The ability of CDKN3 to bind multiple cyclin-dependent kinases suggests that it may be a critical control element in cell cycle regulation, presumably by regulating the phosphorylation state of a Cdk or Cdk-associated protein.
Subcellular location: Cytoplasm
Synonyms: Cdk associated protein phosphatase, CDI1, CDK2 associated dual specicity phosphatase, CIP2, Cyclin dependent kinase inhibitor 3, Cyclin dependent kinase interactor 1, Cyclin dependent kinase-interacting protein 2, KAP1, Kinase associated phosphatase.
Target Information: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]