Description
Product Characteristics:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Subcellular location: Nucleus
Synonyms: 70 kDa ribosomal protein S6 kinase 2, p70 beta, p70 ribosomal S6 kinase beta, p70 S6 kinase beta, p70 S6KB, p70 S6Kbeta, p70S6K beta, p70-beta, p70-S6KB, p70S6Kb, Ribosomal protein S6 kinase 70 kDa, polypeptide 2, Ribosomal protein S6 kinase beta 2, Ribosomal protein S6 kinase beta-2, RPS6KB2, S6 kinase related kinase, S6 kinase-related kinase, S6K beta 2, S6K beta, S6K-beta, S6K2, Serine/threonine protein kinase 14 beta, Serine/threonine-protein kinase 14 beta, SRK, STK14B.
Target Information: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jul 2008]