Description
Product Characteristics:
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains.
Subcellular location: Cytoplasm
Synonyms: CPLA2 beta, Cytosolic phospholipase A2 beta, DKFZp686N12131, FLJ17693, FLJ42498, FLJ53173, PA24B_HUMAN, HsT16992, OTTHUMP00000201605, OTTHUMP00000210673, Phospholipase A2 group IVB, Phospholipase A2, group IVB cytosolic, PLA2G4B.
Target Information: This gene transcribes naturally-occurring mRNAs that are read-through products of the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (PLA2G4B) genes. These read-through products contain in-frame segments from both genes but a function has yet to be determined for the predicted fusion proteins, which contain a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2011]