Description
Product Characteristics:
Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into hiding,? the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment, successful treatment will usually eliminate HBeAg from the blood and lead to development of against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen, these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.
Synonyms: Hepatitis B, Core antigen, Core protein, HBe antigen, HBeAg, HBVgp4, Pre C,C, Precore protein, Precore/core, Precore/core ORF, Precore/core protei, HBEAG_HBVD3, External core antigen, HBeAg, p25.
Target Information: Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre- genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions. {ECO:0000255:HAMAP-Rule:MF_04076}. Encapsidates hepatitis delta genome. {ECO:0000255:HAMAP- Rule:MF_04076}