Description
Product Characteristics: This antibody reacts with the X chain of the CD11c/CD18 integrin heterodimer expressed on monocytes and weakly on granulocytes. The antibody stains macrophages in most types of tissues. flow cytometry the antibody labels a T-cell subset and weakly a B-cell subset.
Target Information: This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq, Jul 2008]