Description
Product Characteristics:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
Subcellular location: Cytoplasm
Synonyms: Arhgap8, AU043908, C030017C09Rik, C78947, FLJ20185, FLJ20185k, MGC109513, MGC32512, PP610, Proline rich 5 renal, Proline-rich protein 5, Protein observed with Rictor-1, Protor-1, PROTOR1, PRR5, PRR5_HUMAN, PTOR1, RP1-181C9.3.
Target Information: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]