Description
Product Characteristics:
DAB2IP is a Ras GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. It also interacts with MAP3K5 to disrupt the association of MAP3K5 with the inhibitory 14-3-3 complex.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: AF9Q34, AIP1, ASK interacting protein, DAB2P_HUMAN, ASK interacting protein 1, ASK1 interacting protein 1, DAB2 interacting protein, DAB2 interaction protein, DAB2P, DIP1/2, Disabled homolog 2 interacting protein, DOC 2/DAB2 interactive protein, FLJ39072, KIAA1743, nGAP like protein.
Target Information: DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]