Description
Product Characteristics:
Together with dynein may be involved in spindle assembly and cytokinesis.Tissue specificity:Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
Subcellular location: Cytoplasm, Nucleus
Synonyms: DCNT22, DCTN 22, DCTN22, Dctn3, DCTN3_HUMAN, dynactin 3 p22, dynactin 3, dynactin 3 isoform 1, Dynactin complex subunit 22 kDa subunit, dynactin light chain, Dynactin subunit 3, p22.
Target Information: This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]