Description
Product Characteristics:
GAI3 is the a subunit of inhibitory trimeric G protein (Gi), which inhibits adenylate cyclase once its G protein coupled receptors (GPCR) such as a2 adrenergic receptors are activated. GAI3 can be inactivated by pertussis toxin. Guanine nucleotide binding proteins are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor regulated K(+) channels.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: GAI3, 87U6, FLJ26559, G protein alpha inhibiting 3, Gi alpha 3, Gi alpha-3, GNAI3, GNAI3_HUMAN, Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 3, Guanine nucleotide binding protein Gk alpha subunit, Guanine nucleotide-binding protein Gk subunit alpha, OTTHUMP00000013368, Gnai3, Guanine nucleotide binding protein G protein, alpha inhibiting 3, G Alpha i-3.
Target Information: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]