Description
Product Characteristics:
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
Subcellular location: Nucleus
Synonyms: TCF3/E2Aphospho T355, p-TCF3phospho T355, p-E47phospho T355, bHLHb21, Class B basic helix-loop-helix protein 21, E12, E2A, E2A immunoglobulin enhancer binding factors E12/E47, E47, Helix loop helix protein HE47, Immunoglobulin enhancer-binding factor E12/E47, immunoglobulin transcription factor 1, ITF1, Kappa E2 binding factor, Kappa-E2-binding factor, MGC129647, MGC129648, Negative vitamin D response element binding protein, TCF-3, TCF3, TFE2, TFE2_MOUSE, transcription factor 3, Transcription factor E2-alpha, Transcription factor ITF-1, VDIR, VDR interacting repressor.
Target Information: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\,19), with PBX1), childhood leukemia (t(19\,19), with TFPT) and acute leukemia (t(12\,19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]