Description
Product Characteristics:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. MRPL28 is a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA A24 restricted fashion.
Subcellular location: Cytoplasm
Synonyms: RM28_HUMAN, 39S ribosomal protein L28 mitochondrial, 39S ribosomal protein L28 mitochondrial precursor, HGNC6756, L28mt, MAAT 1, MAAT1, Melanoma antigen p15, Melanoma associated antigen recognised by cytotoxic T lymphocytes, Melanoma associated antigen recognized by T lymphocytes, MGC8499, Mitochondrial ribosomal protein L28, MRP L28, MRPL 28, P15.
Target Information: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]