Description
Product Characteristics:
SAA4 is a constitutively expressed protein belonging to the SAA family. It is a major acute phase reactant and an apolipoprotein of the HDL complex. The serum amyloid A (SAA) superfamily comprises a number of differentially expressed genes with a high degree of homology in mammalian species. SAA4, an apolipoprotein constitutively expressed only in humans and mice, is associated almost entirely with lipoproteins of the high density range. Its physiological function is unknown and its serum concentration has no relationship with those of other major apolipoproteins. The presence of SAA4 mRNA and protein in macrophage derived foam cells of coronary and carotid arteries suggested a specific role of human SAA4 during inflammation including atherosclerosis.
Subcellular location: Secreted
Synonyms: C SAA, Constitutively expressed serum amyloid A protein, CSAA, SAA 4, SAA4, SAA4 protein, Serum amyloid A 4 protein, Serum amyloid A4 constitutive, serum amyloid A-4 protein precursor.
Target Information: Major acute phase reactant. Apolipoprotein of the HDL complex