Description
Product Characteristics:
4E-BP2, 4EBP2, eIF4E binding protein 2, eIF4E-binding protein 2, Eif4ebp2, Eukaryotic translation initiation factor 4E binding protein 1, Eukaryotic translation initiation factor 4E-binding protein 2, PHASII.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Regulates e4E activity by preventing its assembly into the e4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.Full=Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, e4E-binding protein 2, 4EBP2_HUMAN.
Target Information: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]