Description
Product Characteristics:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
Subcellular location: Cytoplasm
Synonyms: BAG 3, BAG family molecular chaperone regulator 3, BAG-3, Bag3, BAG3_HUMAN, y Bcl 2 binding protein, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, BCL2 associated athanogene 3, BCL2 binding athanogene 3, BIS, Docking protein CAIR 1, Docking protein CAIR-1.
Target Information: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]