Description
Product Characteristics:
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion.Tissue specificity: Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Bax interacting factor 1, Bax-interacting factor 1, B 1, B-1, CGI 61, Endophilin B1, Endophilin-B1, SH3 domain GRB2 like endophilin B1, SH3 domain-containing GRB2-like protein B1, Sh3glb1, SH3p13, SHLB1_HUMAN.
Target Information: This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]