Description
Product Characteristics:
DHRS3 belongs to the short-chain dehydrogenases/reductases (SDR) family. It catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. DHRS3 is located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors. There are two named isoforms.
Subcellular location: Cell membrane
Synonyms: DD83.1, Dehydrogenase/reductase SDR family member 3, EC 1.1.1.300, MGC125166, RDH17, Retinal short chain dehydrogenase/reductase 1, retSDR1, Rsdr1 antibody SDR family, member 3, SDR1, SDR16C1, Short-chain dehydrogenase/reductase 3, Short-chain dehydrogenase/reductase family, member 3.
Target Information: Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]