Description
Product Characteristics:
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact made up of network of strands that act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition.
Subcellular location: Cell membrane
Synonyms: CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4
Target Information: This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Jul 2008]