Description
Product Characteristics:
HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.
Subcellular location: Nucleus
Synonyms: Homeo box 2F, Homeo box B4, Homeobox 2F, Homeobox B4, Homeobox protein Hox B4, Homeobox protein HoxB4, HOX 2, Hox 2.6, Hox 2F, HOX B4, HOX2, HOX-2 Hox2.6, Hox2F, HOXB 4, HOXB-4.
Target Information: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]