Description
Product Characteristics:
BubR1
Subcellular location: Cytoplasm, Nucleus
Synonyms: Beta homolg of S. cerevisiae BUB 1, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles, BUB 1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta, Bub1A, BUB1B, BUB1B_HUMAN, BUB1beta, BUBR1, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3/BUB1 related protein kinase, MAD3/BUB1-related protein kinase, MAD3L, Mitotic checkpoint gene BUB1B, Mitotic checkpoint kinase MAD3L, Mitotic checkpoint serine/threonine protein kinase BUB1 beta, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Protein SSK1, SSK 1, SSK1.
Target Information: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]