Description
Product Characteristics:
Reg protein is stimulated during the regeneration of pancreatic islets. In human, there are four REG family genes, REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function.
Subcellular location: Secreted
Synonyms: ICRF, Islet cells regeneration factor, Islet of Langerhans regenerating protein, Lithostathine 1 beta, Lithostathine-1-alpha, P19, Pancreatic stone protein 2, Pancreatic stone protein, Pancreatic thread protein, PSP, PSPS, PSPS1, PSPS2, PTP, REG 1 beta, REG, REG-1-alpha, REG1A, REG1A_HUMAN, REG1B, Regenerating islet derived protein 1 beta, Regenerating islet-derived protein 1-alpha, Regenerating protein I alpha, REGL.
Target Information: This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]