Description
Product Characteristics:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
Subcellular location: Cytoplasm
Synonyms: AOP1, MER5, AOP-1, SP-22, HBC189, PRO1748, prx-III, Thioredoxin-dependent peroxide reductase, mitochondrial, Antioxidant protein 1, Peroxiredoxin III, Peroxiredoxin-3, Protein MER5 homolog, PRDX3
Target Information: This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]