Description
Product Characteristics:
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.Tissue specificity:Highly expressed in heart and skeletal muscle.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: PP2C beta, PP2C beta X, PP2C-beta, PP2CB, PP2Cbeta, PPC2BETAX, PPM 1B, Ppm1b, PPM1B_HUMAN, Protein phosphatase 1B formerly 2C magnesium dependent beta isoform, Protein phosphatase 1B, Protein phosphatase 1B magnesium dependent beta isoform, Protein phosphatase 2C beta isoform, Protein phosphatase 2C isoform beta, Protein phosphatase 2C like protein, Protein phosphatase, Mg2+/Mn2+ dependent, 1B, MGC21657.
Target Information: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]