Description
Product Characteristics:
This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.
Subcellular location: Cell membrane
Synonyms: HEPS, HEPS_HUMAN, Hepsin, HPN, Serine protease hepsin, Serine protease hepsin catalytic chain, Serine protease hepsin non catalytic chain, TMPRSS 1, TMPRSS1, Transmembrane protease serine 1.
Target Information: This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]