Description
Product Characteristics: CHIT1, chitinase 1 (chitotriosidase), CHI3, CHIT, FLJ00314, MGC125322, OTTHUMP00000217083, OTTHUMP00000217084, OTTHUMP00000217085, chitinase-1, chitotriosidase-1, plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
Target Information: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]