Description
Product Characteristics:
PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
Subcellular location: Cell membrane
Synonyms: Channel associated protein of synapse 110, Channel associated protein of synapses 110kD, Channel-associated protein of synapse-110, Chapsyn 110, Chapsyn-110, Chapsyn110, discs large homolog 2, Discs, large homolog 2 Drosophila, Disks large homolog 2, DKFZp781D1854, DKFZp781E0954, Dlg 2, dlg2, DLG2_HUMAN, Dlgh 2, Dlgh2, FLJ37266, Gm1197, MGC131811, Postsynaptic density protein PSD 93, Postsynaptic density protein PSD-93, Postsynaptic density protein PSD93, PSD 93, PSD93.
Target Information: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]