Description
Product Characteristics: ADAM-TS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. ADAM-TS1 has angiogenic inhibitor activity. Active metalloprotease may be associated with various inflammatory processes as well as development of cancer cachexia. ADAM-TS1 may play a critical role in follicular rupture. ADAM-TS1 cleaves aggrecan at the 1691-Glu-:-Leu1692 site, within the chondroitin sulfate attachment domain. It binds 1 zinc ion per subunit. ADAM-TS1 is a secreted protein and is associated with the extracellular matrix.It is induced in vitro in colon adenocarcinoma cells by interleukin-1, or in vivo in kidney and heart by lipopolysaccharide and it is also induced by LH stimulation in granulose cells of preovulatory follicles. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. ADAM-TS1 contains 1 disintegrin domain, 1 peptidase M12B domain, and 3 TSP type-1 domains.
Target Information: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]