Description
Product Characteristics: The DDB2 gene plays a role in DNA repair by forming with DDB1 the UV-damaged DNA-binding protein complex (UV-DDB). Binds to pyrimidine dimers. Component of the RBX1-CUL4-DDB2 ubiquitin ligase. Required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. Synonyms: Monoclonal DDB2 antibody, Anti-DDB2 antibody, Damage specific DNA binding protein 2 antibody, FLJ34321 antibody.
Target Information: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]