Description
Product Characteristics:
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular location: Secreted
Synonyms: Granulocyte-Macrophage Colony Stimulating Factor, Burst Promoting Activity, CMCSF, Colony Stimulating Factor 2, Colony stimulating factor, CSF 2, CSF Alpha, CSF, CSF2, Eosinophil Colony Stimulating Factor, GMCSF, Granulocyte Macrophage Colony Stimulating Factor, MGC131935, MGC138897, Molgramostin, Pluripoietin Alpha, Sargramostim, granulocyte-macrophage colony-stimulating factor precursor, CSF2_HUMAN.
Target Information: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]