The Anti-Human Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b) Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CXCL4L1, and PF4V1. This antibody recognizes Human antigen. The Anti-Human Platelet Factor 4 (requires heparin for binding),Purified (Clone: KKO) (Mouse IgG2b) Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FcgammaIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation. (clone KKO), unlike (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT