Description
Product Characteristics:
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Subcellular location: Nucleus
Synonyms: Hsk1, CDC7L1, HsCDC7, huCDC7, Cell division cycle 7-related protein kinase, CDC7-related kinase, CDC7
Target Information: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]