Description
Product Characteristics:
LEFTY2 is a member of the TGF-beta family of proteins. LEFTY2 is secreted and plays a role in left-right asymmetry determination of organ systems during development and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
Subcellular location: Secreted
Synonyms: EBAF, Endometrial bleeding associated factor left right determination factor A transforming growth factor beta superfamily, Endometrial bleeding associated factor, Endometrial bleeding-associated factor, Left right determination factor 2, Left right determination factor A, Left-right determination factor 2, Left-right determination factor A, LEFTA, LEFTY 2, LEFTY2, LEFTYA, LFTY2_HUMAN, MGC46222, Protein lefty 2, Protein lefty A, Protein lefty-2, Protein lefty-A, Protein lefty2, PSEC0024, TGF beta 4, TGF-beta-4, TGFB4, Transforming growth factor beta 4, Transforming growth factor beta-4.
Target Information: This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]