Description
Product Characteristics:
IL31RA is related to gp130 (IL6ST, MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR, MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM].
Subcellular location: Cell membrane
Synonyms: Interleukin-31 receptor subunit alpha, interleukin-31 receptor subunit alpha precursor, cytokine receptor NR10, mGLM-R, IL-31RA, zcytoR17, IL-31R-alpha, gp130-like receptor, IL-31R subunit alpha, novel cytokine receptor 10, IL-31 receptor subunit alpha, gp130-like monocyte receptor, interleukin 31RA, class I cytokine receptor, Il31ra, CRL3, CRL 3,GLM-R, Glmr, GPL, NR10, HGLM R, HGLMR, IL 31RA, Interleukin 31 receptor A, MGC125346, PRO21384, Soluble type I cytokine receptor CRL3, IL31R_HUMAN.
Target Information: The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]