Description
Product Characteristics:
KIRREL2 is an immunoglobulin super family gene, it has been found to be expressed in beta cells of pancreatic islets, KIRR2_HUMAN.
Subcellular location: Cell membrane
Synonyms: NLG1, NEPH3, FILTRIN, Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, Nephrin-like protein 3, KIRREL2, UNQ5827/PRO19646
Target Information: This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]