Fig 1: MiR-145-5p reversed the tumor-promoting effects of circDUSP16 in GC cells. a MTT and b transwell analysis of the effects of co-transfection with circDUSP16 and miR-145-5p mimic on cell proliferation and invasive potential in BGC-823 and SGC-7901 cell lines. c Schematic representation of the binding sites between miR-145-5p and WT or Mut IVNS1ABP 3' UTR. d Luciferase activity of WT or Mut IVNS1ABP 3' UTR after co-transfection with miR-145-5p mimic and WT or Mut IVNS1ABP 3' UTR reporter in BGC-823 and SGC-7901 cell lines. e qRT-PCR and Western blot analysis of IVNS1ABP expression levels after co-transfection with circDUSP16 and miR-145-5p mimic in BGC-823 and SGC-7901 cells. Data shown are the mean ± SEM of three experiments. *P < 0.05; **P < 0.01