Fig 2: TNFSF13B/TNFRSF13B signal contributes to the canonical NF-kB signaling and the proliferation of MM cell. (A) Primary myeloma cells were derived from the patients with multiple myeloma. The expression of TNFRSF13B and TNFRSF17 on the myeloma cells. The data shown in the dot plot are the means ± SD of six samples from three independent experiments. (B) Myeloma cells were cultured with TNFSF13B either in the absence or presence of Bortezomib for 24 h. FACS plots indicate the proportion of KI67+ proliferative cells. The data shown in the dot plot are the means ± SD of six samples from three independent experiments. (C) The phosphorylation of p38 and (D) p65 has been demonstrated in FACS histogram after 30 min of treatment with TNFSF13B either in the presence or absence of Bortezomib. The data shown are the means ± SD of six samples from three independent experiments. ***P < 0.001.