Description
Product Characteristics: FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. Tissue specificity: Heart and uterus. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein.,Voltage-gated,Sodium channel protein type VII subunit alpha, Putative voltage-gated sodium channel subunit alpha Nax, Sodium channel protein cardiac and skeletal muscle subunit alpha, SCN7A, SCN6A, Nax
Target Information: This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics\, the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels\, domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]