Description
Product Characteristics: Function: May participate in the activation of NFKB1 in response to ligation of TNFRSF1A. Could serve as a scaffolding protein to link TNFRSF1A to the IKK signalosome.
Subunit: Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Also known as: Menthol receptorTrp4-associated protein, Short transient receptor potential channel 4-associated protein, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TAP1 protein, Rabex-5/Rin2-interacting protein, TP4AP, Trpc4-associated protein, Trrp4ap.
Target Information: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1