Description
Product Characteristics: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Catalytic activity: An aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H. Subcellular location: Cytoplasm. Tissue specificity: High levels in stomach, esophagus and lung, low level in the liver and kidney.,Cell Biology,AL3A1, Aldehyde dehydrogenase, dimeric NADP-preferring, Aldehyde dehydrogenase family 3 member A1, Aldehyde dehydrogenase 3, ALDHIII, ALDH3A1, ALDH3
Target Information: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]