Description
Product Characteristics: Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Tissue specificity: Expressed in prolactin-secreting adenomas. Subcellular location: Membrane, Multi-pass membrane protein.,Voltage-gated,Potassium voltage-gated channel subfamily H member 6, Voltage-gated potassium channel subunit Kv11.2, Ether-a-go-go-related gene potassium channel 2, Ether-a-go-go-related protein 2, Eag-related protein 2, ERG2, HERG2
Target Information: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]