Description
Product Characteristics: FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.,G Protein Signaling,Mas-related G-protein coupled receptor, member D, Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD
Target Information: seven transmembrane domain G-protein coupled receptor\, most often found in sensory neurons [RGD, Feb 2006]