Description
Product Characteristics: DCUN1D1, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae), DCUN1L1, RP42, SCCRO, SCRO, Tes3, RP42 homolog, squamous cell carcinoma-related oncogene
Target Information: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity)